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chapter15 - BCH 4054 Spring 2001 Chapter 15 Lecture Notes...

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Chapter 15, page 1 BCH 4054 Spring 2001 Chapter 15 Lecture Notes Slide 1 Chapter 15 Enzyme Regulation Slide 2 Enzyme Specificity Molecular recognition through multiple interactions between substrate and enzyme H-bonds, ionic forces, hydrophobic binding, van der Waals binding Lock and Key Model (Emil Fischer) Induced Fit Model (Daniel Koshland) Example of hexokinase (See Fig. 15.1) Slide 3 Control of Enzyme Activity Product accumulation Substrate and coenzyme availability Synthesis and degradation of enzyme Covalent modification Allosteric regulation by “effector molecules” Specialized controls (zymogens, isozymes, modulator proteins)
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