chapter16

chapter16 - BCH 4053 Summer 2001 Chapter 16 Lecture Notes...

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Chapter 16, page 1 BCH 4053 Summer 2001 Chapter 16 Lecture Notes Slide 1 Chapter 16 Mechanisms of Enzyme Action Slide 2 Enormous Rate Acceleration • Rate accelerations by enzymes over uncatalyzed reactions can be very large, as much as 10 16 . (See Table 16.1 for examples) • A goal of studying enzyme mechanisms is to understand the factors contributing to this acceleration. Slide 3 Stabilization of Transition State • Enzyme binds transition state better than it binds substrate • Energy of EX lowered more than energy of ES. (See Figure 16.1) • Some factors “destabilize” the ES complex, bringing it closer in energy to EX . • (See Figures 16.2 and 16.3)
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Chapter 16, page 2 Slide 4 Some Important Catalytic Mechanisms Destabilizing ES complex 1. Entropy loss in ES formation (Fig. 16.4) 2. Strain, desolvation, electrostatic effects (Figures 16.5 and 16.6) Stabilizing EX 3. Covalent catalysis (Fig. 16.9) 4. General acid or base catalysis (Fig. 16.11) 5. Metal ion catalysis (Fig. 16.13)
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This note was uploaded on 05/22/2011 for the course BCH 4053 taught by Professor Logan during the Fall '06 term at FSU.

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chapter16 - BCH 4053 Summer 2001 Chapter 16 Lecture Notes...

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