190lec8 - HKIN 190: Anatomy and Physiology I 8...

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8 – Neurophysiology: Introduction HKIN 190: Anatomy and Physiology I
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Learning Objectives: 1. To understand electrical activity of neurons. Within this, to understand: a. The properties of the plasma membrane. b. The difference between a graded and an action potential. c. The different “stages” of the action potential. d. Factors that influence the speed of the action potential.
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Tissue types in the body CMEN C onnective Tissue Blood Bone Cartilage Connective Tissue Proper M uscle Smooth Skeletal Cardiac E pithelial Squamous Cuboidal Columnar Pseudostratified Transitional N ervous
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Learning Objective 1 To understand electrical activity of neurons. Within this, to understand: a. The properties of the plasma membrane. b. The difference between a graded and an action potential. c. The different “stages” of the action potential. d. Factors that influence the speed of the action potential.
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extracellular fluid – think water and salt (NaCl) intracellular fluid – think water, K+, proteins, bound phosphate The plasma membrane
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Phospholipids
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How substances cross the plasma membrane
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Types of ion channels Leakage (nongated) channels are always open nerve cells have more K+ than Na+ leakage channels as a result, membrane permeability to K+ is higher Important for resting membrane potential of -70mV in nerve tissue Mechanically gated ion channels respond to mechanical vibration or pressure. Important in sensory receptors, eg: pressure – GRADED potentials Ligand-gated channels open and close in response to a stimulus (eg: Ach) results in neuron excitability – important in GRADED potentials Voltage-gated channels respond to a direct change in the membrane potential (eg: voltage-gated K+ channel) Important in generating ACTION potentials (after GRADED)
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Types of ion channels
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Na + -K + Pump (Na + -K + ATPase) form of active transport (requires ATP) pumps Na + out of the cell pumps K + into the cell
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Resting membrane potential more K+ leaking out more Na+ being pumped out
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Neurons are electrically excitable due to the voltage difference across their membrane and the flow of ions through ion channels in the membrane. Communicate with 2 types of electric signals
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This note was uploaded on 05/21/2011 for the course BHK 190 taught by Professor Janice during the Spring '11 term at The University of British Columbia.

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190lec8 - HKIN 190: Anatomy and Physiology I 8...

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