Adaptive immunity - Overview of Adaptive Immunity Adaptive...

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Overview of Adaptive Immunity • Adaptive immunity is the body’s ability to recognize and defend itself against distinct invaders and their products • Five attributes of adaptive immunity – Specificity – Inducibility – Clonality – Unresponsiveness to self – Memory
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Overview of Adaptive Immunity Involves activity of lymphocytes Two main types of lymphocytes – B lymphocytes (B cells) Mature in the bone marrow – T lymphocytes (T cells) Mature in the thymus Two types of adaptive immune responses – Humoral immune responses – Cell-mediated immune responses
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Overview of Adaptive Immunity [INSERT FIGURE 16.1]
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Overview of Adaptive Immunity Animation: Host Defenses: Humoral Immunity: Overview Animation: Host Defenses: Cell-Medicated Immunity: Overview
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Elements of Adaptive Immunity The Tissues and Organs of the Lymphatic System – Screen the tissues of the body for foreign antigens – Composed of lymphatic vessels and lymphatic cells, tissues, and organs
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Elements of Adaptive Immunity The Tissues and Organs of the Lymphatic System – Lymphatic vessels and the flow of lymph • Form a one-way system that conducts lymph from local tissues and returns it to the circulatory system – Lymph is a liquid with similar composition to blood plasma, which arises from fluid leaked from blood vessels into surrounding tissues
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Elements of Adaptive Immunity [INSERT FIGURE 16.2]
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Elements of Adaptive Immunity The Tissues and Organs of the Lymphatic System – Lymphoid organs • Primary lymphoid organs – Red bone marrow – Thymus • Secondary lymphoid organs – Lymph nodes – Spleen – Tonsils – Mucosa-associated lymphatic tissue (MALT)
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Elements of Adaptive Immunity [INSERT FIGURE 16.3]
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Elements of Adaptive Immunity Antigens – Properties of antigens • Molecules the body recognizes as foreign and worthy of attack • Body recognizes antigens by three-dimensional regions called epitopes • Include components of bacterial cell walls, capsules, pili, and flagella, as well as proteins of viruses, fungi, and protozoa • Food and dust can also contain antigenic particles
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Elements of Adaptive Immunity [INSERT FIGURE 16.4a]
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Elements of Adaptive Immunity [INSERT FIGURE 16.4b-d]
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Elements of Adaptive Immunity B Lymphocytes (B Cells) and Antibodies – Arise and mature in the red bone marrow – Found primarily in the spleen, lymph nodes, and MALT – Small percentage of B cells circulate in the blood – Major function is the secretion of antibodies
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Elements of Adaptive Immunity B Lymphocytes (B Cells) and Antibodies – Specificity of the B cell receptor (BCR) • Each B lymphocyte has multiple copies of a single type of protein called the B cell receptor • Each B cell generates a single BCR • The two variable regions of the BCR form the antigen-binding sites
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This note was uploaded on 05/24/2011 for the course BIO 119 taught by Professor Stevendroho during the Spring '11 term at Moraine Valley Community College.

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Adaptive immunity - Overview of Adaptive Immunity Adaptive...

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