Phencyclidine The dust of angles

Phencyclidine The dust of angles - The Dawn of a New Age...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
The Dawn of a New Age T April, 1956 : The pharmaceutical company Parke & Davis first synthesize what they believe to be the perfect anesthetic (Souza, 1995). When administered to patients, it causes a completely dissociative state, with no significant respiratory or cardiovascular depression. Patients appear to be awake, eyes open, breathing normally.but are unaware of their surroundings or the procedures being performed upon them (Souza, 1995). Indeed, this is the perfect drug. Unfortunately, like all good things, this one has a darker side. 15% of patients awake from their slumber with what appeared to be an acute case of paranoid schizophrenia (Peterson; Stillman, 1978). The drug is PCP, and to this day it is the scourge of the underground drug community, and the focal point of intense scientific research. Parke Davis and Company did not know how terrible, and wonderful, a discovery they made that day; but our world has been changed forever because of it.quite possibly for the better. w The Dust of Angels T Phencyclidine, more commonly known as PCP, is a polycyclic compound belonging to the arylcyclohexylamine class of chemicals [figure 1.0] (Souza 1993). In pure form, it is a white powder which readily dissolves in water. The cyclohexamines are known for their the potent neurological effects, with PCP being the most potent. Almost every variation has been administered to, or abused by, humans at some time (Nintey Fifth Congress, 1978). All these compounds have similar pharmacological effects, which vary considerably according to the amount administered. Small doses produce a `drunken' state, in which subjects report a numbness in the extremities, while some species (like dogs and cats) become quite excited (Halberstadt, 1995). Intermediate doses have anesthetic and analgesic effects , with the psychic state resembling sensory isolation with one important exception: the sensory impulses (when tested electrophysiologically) reach the neocortex but "the neuronal signals are grossly distorted" (Halberstadt, 1995). Large doses, especially of PCP, may produce convulsions. Any dose produces cataleptoid muscle effects (Halberstadt, 1995). All the chemicals in this class produce a range a physiological effects, including tachydardia and hypertension (Halberstadt, 1995). Unlike the other cyclohexamines, however, PCP causes severe "emergence delirium" when taken in moderate to anesthetic quantities (Halberstadt, 1995). On the other hand,
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
ketamine, a close cousin of PCP, produces depressant effects which are more amplified than PCP without the psychotic aftereffects (although hallucinations are reported by patients during sedation, (Halberstadt, 1995)). In special cases, ketamine is still used as an anesthetic. (C.H. Badenhorst M.D, personal communication).
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 05/21/2011 for the course ACCT 101 taught by Professor All during the Spring '11 term at Kaplan University.

Page1 / 10

Phencyclidine The dust of angles - The Dawn of a New Age...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online