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The Hormonal Control of Sexual Development

The Hormonal Control of Sexual Development - The objectives...

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The objectives of this article as I saw them were, (1) to show how fetal gonads acquire the ability to function as endocrine organs, and (2), to show the mechanisms by which the endocrine secretions modulate male development. The researchers went through an extremely extensive explanation of the formation of the sexual phenotypes by detailing the development of germ cells. They explained how women's and men's gonads appear identical until Leydig cells, which synthesize testosterone, appear in the connective tissue. This is when differentiation begins. The mechanism that this differentiation occurs is as follows. There are two duct systems which are basically sex specific. In men, Wolffian ducts are dominant and Mullerian ducts are regressive. Whereas in women it is just the opposite. Jost believed that the fetal testis secret a hormone which causes such a differentiation. In order to confirm this belief, he removed the gonads from embryos, prior to the onset of phenotypic differentiation.
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