Lecture 19 Stress and Arousal revised 3 per page

Lecture 19 Stress and Arousal revised 3 per page - 4/11/11...

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4/11/11 1 Parkinson's Disease Parkinson's patients suffer from a loss of dopaminergic neurons in the substantia nigra, which sends processes into the striatum. Insufficient release of dopamine in the striatum disregulates basal ganglia circuitry. The result is loss of movement control, rigidity, postural instability, and tremors. Treatment of Parkinson's Disease The first effective form of treatment was L- dopa, precursor for dopamine. As the disease progresses, the therapeutic effects of L-dopa decrease. Stem cell or fetal tissue implants Lesion globus pallidus or subthalamic nucleus Deep brain stimulation
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4/11/11 2 Summary Dopamine is involved in reward-related learning. There is also evidence for an important role for dopamine in response vigor, stimulus salience and other factors related to reward-seeking. Dopamine is critical for motor control and contributes to psychosis and so it is more than just the reward signal. Pharmacological Treatments for Drug Abuse Key issues Acute detoxification vs prevention of relapse Harm reduction vs total abstience Social drinkers, nicotine gum/patch Aversion Treatment – disulfiram (antabuse) Anti-craving drugs – naltrexone, acamprosate Others in development – topiramate, valproate, selective serotonin reuptake inhibitors [SSRIs], atypical antipsychotic
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This note was uploaded on 05/23/2011 for the course PSYC 2011 taught by Professor > during the Three '11 term at University of Sydney.

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Lecture 19 Stress and Arousal revised 3 per page - 4/11/11...

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