Lecture 18 Dopamine and Addiction 1 per page

Lecture 18 Dopamine and Addiction 1 per page - Neurobiology...

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Unformatted text preview: Neurobiology of Addiction and Treatments Key Questions What are the major features of addiction? What learning mechanisms contribute to addiction? What neuropathology accompanies addiction? What are some potential strategies for the treatment of addiction? Wickens: 458-478 (rest of Chapt. 12 previously assigned) http://www.alcohol.gov.au/ Factors influencing use 1. Rewarding effects of drug 2. Individual expectations of use 3. Cultural influences 4. Social feedback/peer group selection Continuum of Drug Use 1. Total abstinence 2. Rare/social use 3. Heavy social use/early problems 4. Heavy problem use/early addiction 5. Clear addiction/dependency NDS Household Survey Data 2004: recreational drug use in Australia Source: http://www.aihw.gov.au/publications/index.cfm/title/10122 9% of Australians are daily drinkers The Killer Drugs Number of deaths in year 2004-2005 Tobacco 15,050 Alcohol 3,494 Opiates 221 Stimulants 17 Cannabis 1 Collins and Lapsley (2007) The costs of tobacco, alcohol and illicit drug abuse to Australian society in 2004/05. http://www.nationaldrugstrategy.gov.au The Killer Drugs Number of deaths in year 2004-2005 Tobacco 15,050 Alcohol 3,494 Opiates 221 Stimulants 17 Cannabis 1 Collins and Lapsley (2007) The costs of tobacco, alcohol and illicit drug abuse to Australian society in 2004/05. http://www.nationaldrugstrategy.gov.au 0 2000 4000 6000 8000 10000 reduction in workforce absenteeism premature death sickness total labour costs road accidents alcohol tobacco Illicit drugs 0 500 1000 1500 2000 alcohol tobacco Illicit drugs http://www.nationaldrugstrategy.gov.au The Expense of Drugs Australian Institute of Health & Welfare 2003 data Elements of addiction 1. Craving or compulsion 2. Loss of control 3. Little concern for consequences Definition A maladaptive pattern of substance use, leading to clinically significant impairment or distress, as manifested by three of the following, occurring at any time in the same 12-month period: 1. Tolerance 2. Withdrawal 3. Taking larger amounts or over a longer period than was intended 4. A persistent desire or unsuccessful efforts to cut down or control substance use 5. A great deal of time is spent in activities necessary to obtain the substance, use the substance, or recover from its effects 6. Important social, occupational, or recreational activities are given up or reduced because of substance use 7. The substance use is continued despite knowledge of having a persistent or recurrent physical or psychological problem DSM-IV TR Definition A maladaptive pattern of substance use, leading to clinically significant impairment or distress , as manifested by three of the following, occurring at any time in the same 12-month period: 1. Tolerance 2. Withdrawal 3. Taking larger amounts or over a longer period than was intended 4. A persistent desire or unsuccessful efforts to cut down or control substance use 5. A great deal of time is spent in activities necessary to obtain the 5....
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This note was uploaded on 05/23/2011 for the course PSYC 2011 taught by Professor > during the Three '11 term at University of Sydney.

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Lecture 18 Dopamine and Addiction 1 per page - Neurobiology...

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