Lecture 21 1 per page

Lecture 21 1 per page - Amino Acids: Glutamate and GABA...

Info iconThis preview shows pages 1–11. Sign up to view the full content.

View Full Document Right Arrow Icon
Amino Acids: Glutamate and GABA
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 2
Glutamate Most abundant excitatory neurotransmitter Involved in neuronal plasticity related to learning and memory and drug exposure Involved in excitotoxicity following stroke or ischemia and possibly some neurodegenerative diseases AGONISTS – NMDA, AMPA, kainate, ibotenate ANTAGONISTS - AP5, ketamine, PCP, MK-801
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
AMPA (kainate)
Background image of page 4
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Long Term Potentiation (LTP) Let us assume that the persistence or repetition of a reverberatory activity (or "trace") tends to induce lasting cellular changes that add to its stability. ... When an axon of cell A is near enough to excite a cell B and repeatedly or persistently takes part in firing it, some growth process or metabolic change takes place in one or both cells such that A's efficiency, as one of the cells firing B, is increased (Donald Hebb, 1949) Neurons that fire together wire together
Background image of page 6
LTP
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Long Term Potentiation (LTP) a long-lasting enhancement in signal transmission between two neurons that results from stimulating them synchronously May be one way that synaptic strength can be modified by experience to produce learning and lasting memories
Background image of page 8
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Insertion of more AMPA Receptors
Background image of page 10
Image of page 11
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 05/23/2011 for the course PSYC 2011 taught by Professor > during the Three '11 term at University of Sydney.

Page1 / 32

Lecture 21 1 per page - Amino Acids: Glutamate and GABA...

This preview shows document pages 1 - 11. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online