Cell Division1a

Cell Division1a - Lectureobjectives 1....

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Lecture objectives 1. To understand how cell division happens  (rules, signals for cell growth) 2. To understand how genes (DNA) is  packaged and divided during cell division 3. To understand the events of mitosis 4. To understand how mitosis is controlled 5. To understand the consequence of  uncontrolled cell division (cancer)
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Experiments with living cells suggest cells follow  “rules” for growth in a multicellular organism 1. Cells are  anchorage dependent   cells grow on surfaces made by other cells 2. Cells are  growth factor dependent   cells grow only when signalled by other cells 3. Cells exhibit  density-dependent growth inhibition   Cells grow when sparse Cells stop growing when dense          Multi-cellularity  A “Social Contract” of Cells           
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How do cells know they are: contacting a substrate? being signalled by  other cells? in close contact with  other cells? Answer:  Signal transduction  -  a mechanism  that converts a mechanical or chemical  stimulus to a cell into a specific cellular  response
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On On Off On On Off On On On On Genes on/off Signal Transduction -  cell signals sent through  kinases -  proteins that  serves as switches to  activate or deactivate  production of proteins                                                 Sig Signal                                               Amplification Nucleus                                               Cytoplasm            Outside
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Genes on/off Signal Transduction                                  Signal                                                                     Example     Contact                                                                     Substrate
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Cell Division1a - Lectureobjectives 1....

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