7-DNAStructure

7-DNAStructure - History Griffith, 1928 Transforming...

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1 1 DNA and Chromosomes Chapter 5 Dr. Beth Dawson BIO 3, Fall 2010 San José State University 2 History • Griffith, 1928 • Transforming principle ht p:/ en.wikipedia.org/wiki/File:Grif ithm.jpg 3 History • Griffith, 1928 • Transforming principle • 2 strains of Streptococcus pneumoniae – Rough, nonvirulent – Smooth, virulent • Heat killed S, nonvirulent 4 History • Heat-killed S --> nonvirulent • Heat-killed S + R --> virulent • How? – Heat-killed S transforms R to virulent – S can change R into the lethal form 5 History • Griffith, 1928 Figure: ht p:/ en.wikipedia.org/wiki/Grif ith%27s_experiment 6 • Griffith, 1928 Figure 5-3 Essential Cel Biology (© Garland Science 2010)
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2 7 History • Avery, 1944 ht p:/ en.wikipedia.org/wiki/File:Oswald_T._Avery_portrait_1937.jpg 8 History • Avery, 1944 • What molecule causes transformation? – Protein, 20+ amino acids OR – DNA, 4 bases 9 History • Avery, 1944 • What molecule causes transformation? Figure 5-4 Essential Cel Biology (© Garland Science 2010) 10 History ht ps:/ paulingblog.wordpress.com/2009/01/02/the-martha-chase-ef ect/ 11 History • Which is the molecule of inheritance? • Why did they use these two isotopes? 32 P 35 S 12 History Figure 5-5b Essential Cel Biology (© Garland Science 2010) Specific result
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3 13 History • Erwin Chargaff, 1951 ht p:/ history.nih.gov/exhibits/nirenberg/popup_htm/03_chargof .htm 14 History • Erwin Chargaff, 1951 • Earlier hypothesis – ATCG equal amounts – chemistry suggested DNA could not carry information • New equipment - chromatography and spetrophotometer 15 History • Chargaff Rule 1 %A=%T, %G=%C 16 History
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This note was uploaded on 05/24/2011 for the course BIO 3 taught by Professor Dylan during the Spring '11 term at Evergreen Valley.

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7-DNAStructure - History Griffith, 1928 Transforming...

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