17 Cell Cycle 2 - Cell Cycle II Regulation Ch. 12 pp....

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Cell Cycle II Regulation Ch. 12 pp. 238-243 “Growth for the sake of growth is the ideology of the cancer cell.” Edward Abbey
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I. The cell cycle clock (or engine) A series of activation and deactivation reactions of proteins (cyclins and cyclin-dependent kinases) that pace the cell cycle. Timing of phosphorylations, dephosphorylations, protein synthesis and degradation is critically important. Checkpoints are three periods when intercellular signals determine whether to stop, or let the clock run .
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p53 Three checkpoints and their assessments Or = Start Or = M checkpoint
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Three checkpoints: Time Function Alternative G 1 Late in G1 Determine if DNA Enter G 0 state synthesis should begin G 2 G 2 -M border Determine if Mitosis Stop for DNA should begin repair M Mid Mitosis Determine if Mitosis Stop for c some should be completed attachment Know this table
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Fig. 12.13 shows an experiment in which one cell in M and one cell in G1 were fused. The M cell cytoplasm caused premature condensation of chromosomes in the earlier G1 stage nucleus Experimental analysis of cell cycle regulation 1. Experiments showing that _________________________________________. What does this indicate about the Start checkpoint?
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fusion shown in previous slide in which “G 1 nucleus chromosomes are prematurely condensed and appear long and thin upon exposure to “M” phase cell cytoplasm The real data show this: Would the prematurely condensed chromosomes be one chromatid or two? Are there other interpretations of the experiment?
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This note was uploaded on 05/25/2011 for the course BS 111 taught by Professor Patterson during the Winter '05 term at Michigan State University.

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17 Cell Cycle 2 - Cell Cycle II Regulation Ch. 12 pp....

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