7 Cell Cycle 2 Study Guide

7 Cell Cycle 2 Study Guide - BS 111(Kopachik Cell Cycle II...

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BS 111 (Kopachik) Cell Cycle II Terms to know: Cell cycle clock G1checkpoint G2 checkpoint M checkpoint Cyclin Cyclin-dependent kinase (cdk) MPF (Mitosis-promotion-factor) P27 Benign tumor Malignant tumor Density-dependent inhibition Anchorage independence Metastasis 1. Describe the three checkpoints. Give name, location in cell cycle, purpose. 2. What is the evidence that the eukaryotic cell cycle is controlled by cyclins and cyclin dependent kinase activity? What is MPF? What regulatory proteins fluctuate in amount, in activity during phases of the cell cycle and at what time is this done? What cytoskeletal protein’s amount would also vary in the cell cycle? 3. Describe the role of CDK inhibitors and give an example? 4. Describe the G O phase (where is it, when do cells enter it, which cells are in it, how would a cell exit it). 5. Compare and contrast normally regulated growth in cells versus cancer cell growth with respect to: length of the cell cycle, mutations in the genome, ability to divide
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7 Cell Cycle 2 Study Guide - BS 111(Kopachik Cell Cycle II...

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