psychopharmacology - Pharmacodynamics The study of the...

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Pharmacodynamics The study of the effects of drugs Pharmacokinetics Process by which drugs are absorbed, transported, metabolized and eliminated
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Main Routes of Administration Blood Level Time IV or smoked IM, SC or intranasal PO
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Other Routes of Administration Topical Intracerebroventricular Intracerebral
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Dose Response Curve Dose Effect of Drug
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Efficacy Morphine Fentanyl Dose Effect of Drug
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Potency Morphine Fentanyl Dose Effect of Drug Acetaminophen
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Effective Dose Dose % Subjects Showing Effect ED 50
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Lethal Dose Dose % Subjects Dying LD 50
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Therapeutic Index Dose Effect LD 50 ED 50 Margin of Safety
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Therapeutic Index LD 50 ED 50 Higher therapeutic index = safer drug Lower therapeutic index = more dangerous drug
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Agonists Direct agonist Indirect agonist Partial agonist Inverse Agonist
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Direct Agonist Opioid Receptor Endorphin Morphine
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Indirect Agonist
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Partial Agonist Heroin Dose Effect of Drug Buprenorphine
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Inverse Agonist
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Antagonists Competitive Antagonist Non-competitive Antagonist
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Competitive Antagonist Receptor Agonist Antagonist
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Competitive Antagonist Dose-Response Curve Dose Effect Agonist + Competitive Antagonist Agonist Alone
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Non-competitive Antagonist Receptor Agonist Antagonist Receptor Agonist Antagonist Receptor Agonist Ion Channel Antagonist
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Non-competitive Antagonist Dose- Response Curve Agonist Alone Dose Effect of Drug Agonist + Non-competitive Antagonist
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This note was uploaded on 05/25/2011 for the course PSYCHOLOGY 430 taught by Professor Valdez during the Fall '10 term at Grand Valley State University.

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psychopharmacology - Pharmacodynamics The study of the...

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