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CBNS 101 lecture1 - W e lc o m e t o C B N S 1 0 1 CBNS 101...

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CBNS 101 http://www.olympusfluoview.com/gallery/cells/cv1/cv1cells.html , Nathan S. Claxton , Shannon H. Neaves , and Michael W. Davidson Normal African Green Monkey Kidney Fibroblast Cells Welcome to CBNS101
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Suggested text book Molecular Biology of the Cell by Alberts et al . Fifth edition Reading assignments are described on the syllabus.
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The key to every biological problem must finally be sought in the cell . Edmund Wilson, 1925 Cell is the fundamental unit of life Why study Biology of the cell?
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Cell biology occupies a central position between molecular Biology and developmental Biology Animal cell Plant cell Organism Central dogma
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Insights into the basis of cell function is essential to gain insights into human health and disease Regulated cell division >>>>>>> No Cancer Unregulated cell division >>>>>>> Cancer
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What is a cell? Whar are its contents? What is their function?
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Universal features of cells on earth 1) Hereditary information is stored in DNA >>> Chemical code The sequential arrangement of A,T,G,C determines the biology of cells and organisms Whole genome sequencing: Entire sequence of genomes Can be elucidated. Human, several species of bacteria, yeast, Rice, Arabidopsis
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2) All cells replicate their DNA by template ploymerization
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3. All cells follow the central dogma
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4. All cells use proteins as catalysts Example : Lysozyme catalytic site breaking polysaccharide molecule due to the covalent-bond breaking reaction catalyzed by the aminoacids lining the groove
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5) All cells are bounded by plasma membrane: Nutrients and waste material must pass through plasma membrane -- Selective barrier to acquire nutrients -- To retain cellular contents -- Without plasma membrane, the cell can not function as a coordinated chemical system
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6) All cells utilize conserved metabolic pathways to convert food or sunlight into the universal “energy currency” adenosine triphosphate (ATP)
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