CBNS 101 lecture7

CBNS 101 lecture7 - Intracellular Compartments and Protein...

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Intracellular Compartments and Protein Sorting
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Intracellular Compartments and Protein Sorting Unlike bacteria, an eucaryotic cell is subdivided into functionally distinct membrane enclose compartment Each compartment, organelle contains its own characteristic set of enzymes and other Complex molecules. There is also a complex distribution systems transport specific products from one Compartment to an other To understand an eukaryotic cell it is essential to know: -what occurs in each compartment -how molecules move between them -how compartments are created and maintained. An animal cells contains about 10 billion protein molecules and between 10,000 to 20,000 different kinds. The synthesis of almost all these proteins begin in the cytosol. Each newly synthesized molecule is then delivered specially to cell compartment that requires it
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Many vital biochemical processes take place in or on membrane surfaces . -The lipid metabolism for example is mostly catalyzed by membrane bound enzymes -Oxydative phosphorylation and photosynthesis require a membrane to couple the transport H + to the synthesis of ATP Intracellular membrane systems do much more for the cell than increasing membrane area -Creation of an enclose compartment that are separate from the cytosol -Provide the cell with functional aqueous spaces The lipid layer is impermeable to hydrophilic molecules the membrane of each organelle must contain membrane transport proteins responsible for the import or export of specific Proteins Mechanism of import and export is specific for each organelle making the organelle Unique. Nucleus Mitochondria Endoplasmic Reticulum Golgi apparatus Lysosome Peroxisome endosome free polyribosomes cytosol Plasma membrane The compartmentalization of Cells
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Nucleus Mitochondria Endoplasmic Reticulum Golgi apparatus Lysosome Peroxisome endosome free polyribosomes cytosol Plasma membrane Organelles found in a typical animal cell. The compartmentalization of Cells
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The compartmentalization of Cells EM of a liver cell seen in cross section
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The compartmentalization of Cells Mitochondria Endoplasmic Reticulum Golgi apparatus Lysosome Peroxisome endosome free polyribosomes cytosol Plasma membrane
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The compartmentalization of Cells Nucleus Mitochondria Endoplasmic Reticulum Golgi apparatus Lysosome Peroxisome endosome free polyribosomes cytosol Plasma membrane
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Compartment Main Function Cytosol contains many metabolic pathways; protein synthesis Nucleus contains main genome; DNA and RNA synthesis Endoplasmic synthesis of most lipids; synthesis of proteins for distribution reticulum (ER) to many organelles and to the plasma membrane Golgi apparatus modification, sorting, and packaging of proteins and lipids for secretion or delivery to another organelle Lysosomes intracellular degradation Endosomes sorting of endocytosed material Mitochondria ATP synthesis by oxidative phosphorylation Peroxisomes oxidation of toxic molecules Chloroplasts ATP synthesis and carbon fixation by photosynthesis (in plant cells)
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This note was uploaded on 05/26/2011 for the course CBNS 101 taught by Professor - during the Spring '08 term at UC Riverside.

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CBNS 101 lecture7 - Intracellular Compartments and Protein...

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