CBNS 101 lecture11

CBNS 101 lecture11 - C e ll J u n c t io n s a n d C e ll A...

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1996 2ed place, Nikon Small World Competition, Brad Miller, Neurons in cerebral cortex of a six day old rat Cell Junctions and Cell Adhesion
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Multi-cellular organisms forms most beautiful and most wondrous ….. Charles Darwin How cells are organized into tissues? -cell adhesion and the ECM How do cells communicate with each other & with their environment? -cell signaling How do cells control their proliferation?
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TISSUES-The organizational basis of multi-cellular life. Tissues are composed of a variety of differentiated cell types and an extracellular matrix. Structure- The organization of tissues provides mechanical integrity to otherwise squishy cells. Function- Tissue organization allows cells to communicate with one another and to perform specialized functions in a coordinated way. Requires that cells recognize & bind to one another or the ECM.
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Tissues in animal cells display two architectural extremes. Epithelial tissues Connective tissues Epithelial sheets line all body cavities. The cells tightly adhere to one another via anchoring junctions. There is limited extracellular matrix and cells themselves bear mechanical stress. Mechanical strength and specialized functions provided primarily by the extracellular matrix. Specialized cell types secrete the matrix and form few permanent attachments.
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Basal lamina Human skin provides a classic example of these two types of tissue organization
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How are tissues formed during development? Cell division followed by cell adhesion Cell migration and selective adhesion
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Tissue “sorting out” experiments suggest that specific mechanisms allow cells to selectively recognize and adhere to each other. Mesoderm Ectoderm Dissociate cells and mix them up
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Cell-Cell recognition and binding are mediated by transmembrane proteins called Cell Adhesion Molecules (CAMs) cytoskeleton CAM This example shows a homophilic interaction between two green cells using a green CAM Green cell Green cell Extracellular matrix Some general principles…. .
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Green cell Red cell This example shows a heterophilic interaction between two different CAMs Extracellular matrix
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This note was uploaded on 05/26/2011 for the course CBNS 101 taught by Professor - during the Spring '08 term at UC Riverside.

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CBNS 101 lecture11 - C e ll J u n c t io n s a n d C e ll A...

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