biol109_am_I

biol109_am_I - Sequence Analysis Hemant Kelkar Center for...

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Sequence Analysis Hemant Kelkar Center for Bioinformatics University of North Carolina Chapel Hill, NC 27599
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Scope of Series Talk I  Overview and BLAST Talk II Protein analysis/Sequence Alignment  Talk III Evolution Genomics and challenges 
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Bioinformatics Mathematical, Statistical and computational  methods that are used for solving biological  problems Glue that holds the “omics” data together
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Help … Is “my sequence” in the databases? Is it similar to any sequence in the DB? Does it have any know motifs/domains that can help  in identification? Is there a structural homolog? Are there any polymorphisms? Genetic Map location? Bioinformatics TOOLS!
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Bioinformatics Tools  Genetic Code  Protein Structure   Protein Evolution   Similarity search e.g.  BLAST , FASTA http://restools.sdsc.edu/biotools/biotools9.html    e.g. CLUSTALW, T-COFFEE, Phylip
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Primary Sequence Databases GenBank  ( http://www.ncbi.nlm.nih.gov/Genbank/index.html )   PIR  ( http://pir.georgetown.edu/ )   Swiss-Prot  ( http://us.expasy.org/sprot/ )    Sequence information as is generated in the  laboratory
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Derived Sequence Databases PFAM ( http://www.sanger.ac.uk/Software/Pfam/ ) : Protein  families based on HMM models InterPRO ( http://www.ebi.ac.uk/interpro/ ) : Protein families and  domains based on functional sites TransFac ( http://www.gene-regulation.com/ ) transcription factor db Cytochrome P450 database ( http://drnelson.utmem.edu/CytochromeP450.html Databases based on functional or phylogenetic  analysis
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This note was uploaded on 05/26/2011 for the course BIO 522 taught by Professor Staff during the Spring '11 term at UNC.

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biol109_am_I - Sequence Analysis Hemant Kelkar Center for...

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