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ProteinSecretion

ProteinSecretion - FIG 1 Schematic representation of the...

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FIG. 1. Schematic representation of the type I, II, III, and IV protein secretion systems. The type I pathway is exemplified by hemolysin A (HlyA) secretion in E. coli , the type III system is exemplified by Yop secretion in Yersinia , the type II system is exemplified by pullulanase secretion in Klebsiella oxytoca , and the type IV system is exemplified by the VirB system in A. tumefaciens . ATP hydrolysis by HlyB, YscN, SecA, and VirB11 is indicated. Secreted effector molecules are depicted as grey ovals. The type II and in some cases the type IV secretion systems utilize the cytoplasmic chaperone SecB, although the Tat export pathway has recently been implicated in the secretion of molecules via the type II pathway. Type III secretion also involves cytoplasmic chaperones (SycE); however, they do not interact with the Sec inner membrane translocon. The major structural proteins of each system are depicted in relation to their known or deduced position in the cell envelope. EM, extracellular milieu; OM, outer membrane; Peri, periplasm; IM, inner membrane; Cyto, cytoplasm.
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