DBLecture6posted

DBLecture6posted - Inducer Neurulation Responder (see...

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Neurulation (see slides posted at end of DB5 ppt) Inducer Responder
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Signaling Inducer Responder
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Signals can act in a graded fashion
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Setting up a signaling gradient: the role of the wingless gene
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Cells know their positions within the body and differentiate accordingly Anterior Posterior A- Hair P- Bare Skin segment
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wild type A = hair P = bare skin To set up this pattern, flies use the secreted protein Wingless to specify a posterior fate segment
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Be Posterior! Cells instruct one another via cell-cell signaling pathways
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Be Posterior! Cell-cell signaling can be influenced by distance between cells Yes Ma'am! Pardon me?
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Anterior: Low Wingless, Hairs Posterior: High Wingless , Naked Cuticle
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Wingless-expressing cells Wingless diffuses away from the cells that secrete it
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Wingless signaling specifies posterior cell fates in the ventral epidermis arm mutant wild type ALL cells have anterior (hair) fate A = hair P = bare skin
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Therefore, all cells can see wingless, and the concentration of wingless itself is what determines cell fate Setting up a signal gradient
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This note was uploaded on 05/26/2011 for the course BIO 205 taught by Professor Reed during the Spring '11 term at UNC.

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DBLecture6posted - Inducer Neurulation Responder (see...

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