DBLecture8posted

DBLecture8posted - Flies are quick! The fly body plan: each...

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Flies are quick!
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The fly body plan: each segment has a unique identity and produces distinctive structures 3 head 3 thorax 8 abdomen
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Model Organisms: Drosophila small (adult < 5 mm long). Can keep hundreds in a small vial. short generation time - 8 days embryo develops outside the body in a short time - so can easily study development history - scientists have been doing genetics and collecting mutations for many years (since 1910) very cheap to keep reproducible anatomy segmentation visible many anatomical, developmental, & behavioral similarities to vertebrates Small Genome = 120 Mb
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Thomas Hunt Morgan and the white eye mutant wildtype fly white mutant
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Christiane Nüsslein-Volhard and Eric Wieschaus used genetics to identify proteins that set up the embryonic body plan
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Wieschaus and Nüsslein-Volhard looked for mutants that affect the fly body plan wildtype
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The fruit fly body plan is self-assembled in 24 hours: how is it specified?
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Anterior-Posterior Pattern Formation in Flies Figure 6.17 Maternal effect genes
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Maternal effect genes establish the anterior/posterior axis of the embryo Posterior Determinant nanos mRNA Anterior Determinant bicoid mRNA Oocyte nurse cells
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bicoid protein accumulates in a gradient 100 0 Level of bicoid A P head tail
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Remember that cleavage starts without cell division in Drosophila (superficial cleavage) Fig. 9.1 Syncytial specification: specification by interactions between cytoplasmic regions rather than cells
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Gene A - turned on only by high level of bicoid Gene B - turned on only by intermediate level of bicoid Gene C - turned off by
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DBLecture8posted - Flies are quick! The fly body plan: each...

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