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Lecture 6 - Signals in frog embryogenesis

Lecture 6 - Signals in frog embryogenesis - Signals in frog...

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Signals in frog embryos How can we identify developmental signaling pathways and test their roles? How do other vertebrate embryos develop?
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Developmental biology jargon Cell fate – the normal future identity of a cell (muscle, skin, etc.). A fate map represents future cell fates. Specification – the process by which a cell acquires a particular fate. Specified cells could still switch to some other fate in response to perceived signals. A specification map represents the identities that cells have acquired at a particular stage. Determination – the process by which cells fix their fate stably. Determined cells do not change fate even if they receive new signals. Differentiation – the process by which cells actually change to take on a particular identity (e.g. express muscle-specific genes).
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~64-cell stage late blastula gastrulation Mesoderm induction and patterning
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What experimental results demonstrate that a particular signal induces a response?
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What experimental results demonstrate that a particular signal induces a response?
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