Lecture 15 - Drosophila D-V axis

Lecture 15 - Drosophila D-V axis - Drosophila...

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Drosophila dorsal/ventral axis detemination How are different tissue types specified at distinct positions on the embryonic dorsal- ventral axis?
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amnio-serosa dorsal  ectoderm neuro- ectoderm mesoderm Cell fate specification at the blastoderm stage mesoderm formation fate map dorsal ventral
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Dorsal-Ventral fate map
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Genes identified in a famous screen for Drosophila mutants with embryo patterning defects Torpedo Gurken
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Localized maternal mRNA sets up anterior and posterior poles
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Gurken protein specifies the Anterior-Posterior axis of the Drosophila embryo during oogenesis (Similar to EGF)
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Gurken also signals dorsal pole formation during oogenesis follicle cells anterior posterior A P V D D V - + - microtubules 7 1-6 8 10A gurken expression in the oocyte 10A gurken expression in the oocyte 1-6 Microtubules reorient, nucleus migrates to minus end + - - 8 oocyte nucleus Gurken mRNA also relocalizes to anterior dorsal side.
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Localization of the Gurken mRNA and protein between the oocyte nucleus and the dorsal anterior cell membrane
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Lecture 15 - Drosophila D-V axis - Drosophila...

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