Lecture 16 - Drosophila A-P axis

Lecture 16 - Drosophila A-P axis - Anterior-posterior...

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Unformatted text preview: Anterior-posterior patterning in Drosophila The fly body plan: Each segment has a unique identity and produces distinct structures 3 head 3 thorax 8 abdomen fate map larva wild-type anterior bicoid posterior oskar terminal torso Mutations affecting the antero-posterior axis 3 independent maternal systems: anterior , posterior , terminal single mutants double mutants triple mutants additive phenotypes active systems A P T- P T A- T A P- --- - P- -- T A-- active systems Maternal effect mutations Zygotic effect mutations Embryo from wild-type mother Embryo from bicoid mother bicoid mutant phenotype Wild-type Bicoid promotes anterior fates and inhibits posterior fates. Wild type blastoderm fate map bicoid mutant Anterior: bicoid is required for head and thorax abdomen abdomen head + thorax Bicoid mRNA localization in embryo (tethered to microtubules) Nuclei divide without cell division in Drosophila to produce a syncytial blastoderm embryo Fig. 9.1 Bicoid protein gradient in syncytial blastoderm embryo- diffuses after translation from localized mRNA- protein unstable...
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This note was uploaded on 05/26/2011 for the course BIO 205 taught by Professor Reed during the Spring '11 term at UNC.

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Lecture 16 - Drosophila A-P axis - Anterior-posterior...

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