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Lecture 19 - T cells and MHC proteins

Lecture 19 - T cells and MHC proteins - T cells and MHC...

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T cells and MHC proteins How does the immune system recognize cells that are infected by a virus? Why doesn't the immune system attack uninfected cells?
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Which cells can restore the immune response? Usually requires both B and T cells
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Clonal selection B cell activation usually requires help from T H cells (except for activation by polyvalent antigens)
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Dendritic cells activate T H cells, then T H cells activate B cells
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Dendritic cells activate T H cells, then T H cells activate B cells T cell receptor MHC II
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T cell receptor (TCR genes are rearranged as antibody genes are in B cells)
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MHC (Major Histocompatibility Complex) proteins
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MHC I binds peptides
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Human MHC ( M ajor H istocompatibility C omplex) genes Highly polymorphic in population Class I - Expressed in almost all cells of body Class II – Expressed in antigen-presenting cells
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T cell receptor recognizes MHC + peptide
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Dendritic cells activate T H cells, then T H cells activate B cells T cell receptor MHC II
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Dendritic cells activate T H cells, then T H cells activate B cells T cell receptor MHC II
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Antigen-presenting cells: Dendritic cells (shown) B cells Macrophages
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Antigen-presenting cells activate T C and T H cells
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Antigen-presenting cells activate T H cells
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Dendritic cells activate T H cells, then T H cells activate B cells T cell receptor
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