Lecture3-3

Lecture3-3 - The role of weak bonds The 20 amino acid...

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1 Protein Structure and Function Most of this material is in chapter 4; basics are in chapter 2. Introduction organization of molecules in cells: atoms, small molecules, macromolecules, supermolecular aggregates. Atoms 95% of cell's dry weight is C, O, H, N, P, S. Na, K, Cl, Ca, Fe, Zn are each present at less than 1%. Small molecules Cells are 70% water, nearly 30% carbon compounds. Molecules are covalently bonded atoms Covalent bonds A handful of functional groups are common in molecules of living cells Four main classes of small molecules (MW = 100-1000): amino acids nucleotides sugars lipids Macromolecules (MW = 1000-1,000,000, consist of subunits linked by covalent bonds) Nucleic acids Polysaccharides Proteins
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2 Weak bonds (panel 2-7 in text) 1. Hydrogen bonds 2. Hydrophobic interactions 3. Ionic bonds 4. van der Waals interactions
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Unformatted text preview: The role of weak bonds The 20 amino acid subunits are grouped by important characterisitics. 3 Protein conformation Four ways of representing protein conformation: backbone model ribbon model wire model space-filling model Common folding patterns: -helix -sheet 4 Proteins have four levels of structural organization: primary (sequence), secondary, tertiary, quaternary X-ray crystallography and NMR spectroscopy- methods for determining protein structure Protein Function Proteins function as enzymes, structural proteins, transport proteins, motor proteins, storage proteins, signaling proteins, receptor proteins, gene regulatory proteins. Protein binding to other molecules ligands binding sites Antibodies How enzymes work Conformational changes in proteins Motor proteins...
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This note was uploaded on 05/26/2011 for the course BIO 205 taught by Professor Reed during the Spring '11 term at UNC.

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Lecture3-3 - The role of weak bonds The 20 amino acid...

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