Lecture4(1)

Lecture4(1) - -7.2 M or pH7.2) 4 x 10-5 (10-7.4 M or pH7.4)...

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1 The lipid bilayer Interactions between lipids and water Fluidity of the bilayer Asymmetry in the bilayer Permeability
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2 Membrane Proteins How proteins associate with the bilayer Studying membrane proteins Bacteriorhodopsin The cell cortex cortex of a red blood cell:
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3 Carbohydrates on the cell surface - lectins: proteins that recognize specific oligosaccharide side chains Mobility of membrane proteins Proteins involved in transport across membranes Ion concentrations inside and outside of cells: Component Intracellular concentration (mM) Extracellular concentration (mM) Cations Na + 5-15 145 K + 140 5 Mg ++ * 0.5 1-2 Ca ++ * 10 -7 1-2 H + 7 x 10 -5 (10
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Unformatted text preview: -7.2 M or pH7.2) 4 x 10-5 (10-7.4 M or pH7.4) Anions Cl-5-15 110 Fixed anions ** high * Free Mg ++ and Ca ++ ions in cytosol. Much more is present bound to proteins or in compartments. ** Fixed anions are the negatively charged small and large organic molecules trapped in the cell. 4 Carrier proteins Passive & active transport of solutes How a carrier protein can allow passive transport of a selected molecule: Active transport 3 ways of driving active transport The Na-K pump - a coupled transporter 5 Gated channels voltage-gated channels ligand-gated channel stress-activated (mechanosensitive) channel:...
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This note was uploaded on 05/26/2011 for the course BIO 205 taught by Professor Reed during the Spring '11 term at UNC.

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Lecture4(1) - -7.2 M or pH7.2) 4 x 10-5 (10-7.4 M or pH7.4)...

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