Lecture4

Lecture4 - 01.21.11 Lecture 4 Cellular Building Blocks:...

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Unformatted text preview: 01.21.11 Lecture 4 Cellular Building Blocks: Lipids and Membranes Membranes form many compartments in the cell Biological membranes are composed of a lipid bilayer and proteins Membrane lipids are amphipathic molecules Membrane lipids are amphipathic Hydrophilic heads (polar) form hydrogen bonds with water Hydrophobic tails (non-polar) are excluded by water molecules Three classes of membrane lipids Packing arrangements of lipid molecules in an aqueous environment Cone-shaped lipid molecules for micelles, cylinder-shaped lipids form bilayers Phospholipid bilayers spontaneously close to form a sealed compartment The membrane bilayer is a fluid Lateral diffusion occurs rapidly within the plane of the membrane Individual phospholipids may rotate axially Flip-flopping from one side to the other is very rare as it is energetically unfavorable The membrane bilayer is a fluid: FRAP 1. A fluorescent probe is used to label membrane proteins 2. The probe is destroyed in a small region using intense laser light 3. Fluorescence microscopy is used to observe behavior of the unbleached probe...
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Lecture4 - 01.21.11 Lecture 4 Cellular Building Blocks:...

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