Lecture4

Lecture4 - 01.21.11 Lecture 4 Cellular Building Blocks Lipids and Membranes Membranes form many compartments in the cell Biological membranes are

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Unformatted text preview: 01.21.11 Lecture 4 Cellular Building Blocks: Lipids and Membranes Membranes form many compartments in the cell Biological membranes are composed of a lipid bilayer and proteins Membrane lipids are amphipathic molecules • Membrane lipids are amphipathic • Hydrophilic heads (polar) form hydrogen bonds with water • Hydrophobic tails (non-polar) are excluded by water molecules Three classes of membrane lipids Packing arrangements of lipid molecules in an aqueous environment Cone-shaped lipid molecules for micelles, cylinder-shaped lipids form bilayers Phospholipid bilayers spontaneously close to form a sealed compartment The membrane bilayer is a fluid • Lateral diffusion occurs rapidly within the plane of the membrane • Individual phospholipids may rotate axially • Flip-flopping from one side to the other is very rare as it is energetically unfavorable The membrane bilayer is a fluid: FRAP 1. A fluorescent probe is used to label membrane proteins 1. The probe is destroyed in a small region using intense laser light 1. Fluorescence microscopy is used to observe behavior of the unbleached probe •...
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This note was uploaded on 05/26/2011 for the course BIO 205 taught by Professor Reed during the Spring '11 term at UNC.

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Lecture4 - 01.21.11 Lecture 4 Cellular Building Blocks Lipids and Membranes Membranes form many compartments in the cell Biological membranes are

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