Lecture5-5

Lecture5-5 - contains two membrane-bounded compartments(0.5...

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How cells generate energy ATP is used to drive energetically unfavorable reactions (such as molecular synthesis, active transport, motility) in coupled reactions. Review 4 major metabolic pathways involved in producing ATP in eukaryotic cells: Glycolysis, Krebs cycle, Electron transport, Oxidative phosphorylation AEROBIC RESPIRATION REACTANTS PROCESS PRODUCTS Glucose ADP H + NAD + GLYCOLYSIS Pyruvate ATP NADH Pyruvate NAD + FAD GDP KREBS CYCLE CO2 GTP FADH NADH NADH FADH2 O2 ELECTRON TRANSPORT H2O H+ ADP OXIDATIVE PHOSPHORYLATION ATP
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Q: How can we determine where in the cell each of these pathways occur? A: Fractionate cell into cytosol and organelles, add individual reactants for one pathway at a time, and then assay for the production of ATP. The mitochondrion
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Unformatted text preview: : contains two membrane-bounded compartments: (0.5 - 1.0 µ m diameter) Q: How can we determine where in the mitochondrion the Krebs cycle occurs? where electron transport and oxidative phosphorylation occur? The electron transport chain generates a proton (H + ) gradient across the inner membrane. This proton gradient drives ATP synthesis. The protein that makes this possible is ATP synthase: matrix space inner mitochondrial membrane intermembrane space Protons flow down their gradient across the inner membrane by passing through a channel in ATP synthase, and this flow causes rotation of part of the ATP synthase. Conformational changes occurring in the rotation are used to phosphorylate ADP, producing ATP....
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Lecture5-5 - contains two membrane-bounded compartments(0.5...

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