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Lecture10-10

Lecture10-10 - Checkpoints The anaphase checkpoint Control...

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1 Cell-Cycle Control, Cell Death, Cancer The Cell-Cycle Control System How are the orderly events of the cell cycle orchestrated? How do cells ensure all the steps of the cell cycle are taken in the right order? The central control system and checkpoints Cyclically activated protein kinases Cyclins MPF The accumulation and destruction of cyclin How CDK activities are regulated
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2 Different cyclin-Cdk complexes trigger different steps in the cell cycle
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Unformatted text preview: Checkpoints The anaphase checkpoint Control of cell numbers in multicellular organisms Cell proliferation depends on signals from other cells Programmed cell death How programmed cell death works 3 Cancer Evidence that cancer is caused by mutations How cancer-causing mutations arise Proto-oncogenes, oncogenes, tumor-suppressor genes Cancer generally involves multiple mutations...
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