{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Lecture10

Lecture10 - 02.08.10 Lecture 10 Cell Communication II GPCR...

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 02.08.10 Lecture 10: Cell Communication II GPCR signaling is inactivated by arrestins Calcium transients trigger many cellular processes • Many signals trigger Ca +2 release (not just GPCRs) • Skeletal muscle contracts in response to calcium release • Ca +2 triggers regulated secretion (I.e. in neurons) • Sperm entry triggers a calcium wave during fertilization Fertilization induces a rise in Ca +2 that starts embryogenesis • Starfish egg loaded with a calcium-sensitive fluorescent dye • Fertilized in vitro and monitored by fluorescence microscopy QuickTimeª and a Animation decompressor are needed to see this picture. Fertilization induces a rise in Ca +2 that starts embryogenesis The effects of calcium in the cytosol are mediated by calcium-binding proteins • Protein kinase C: activated by calcium & DAG • Calmodulin: activated by conformational change by calcium binding • Ca +2 /calmodulin-dependent kinase (Cam-kinase): activated by Ca +2-calmodulin Activation of CaM-kinase 3 classes of cell surface receptors...
View Full Document

{[ snackBarMessage ]}

Page1 / 22

Lecture10 - 02.08.10 Lecture 10 Cell Communication II GPCR...

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon bookmark
Ask a homework question - tutors are online