Lecture10

Lecture10 - 02.08.10 Lecture 10: Cell Communication II GPCR...

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Unformatted text preview: 02.08.10 Lecture 10: Cell Communication II GPCR signaling is inactivated by arrestins Calcium transients trigger many cellular processes Many signals trigger Ca +2 release (not just GPCRs) Skeletal muscle contracts in response to calcium release Ca +2 triggers regulated secretion (I.e. in neurons) Sperm entry triggers a calcium wave during fertilization Fertilization induces a rise in Ca +2 that starts embryogenesis Starfish egg loaded with a calcium-sensitive fluorescent dye Fertilized in vitro and monitored by fluorescence microscopy QuickTime and a Animation decompressor are needed to see this picture. Fertilization induces a rise in Ca +2 that starts embryogenesis The effects of calcium in the cytosol are mediated by calcium-binding proteins Protein kinase C: activated by calcium & DAG Calmodulin: activated by conformational change by calcium binding Ca +2 /calmodulin-dependent kinase (Cam-kinase): activated by Ca +2-calmodulin Activation of CaM-kinase 3 classes of cell surface receptors...
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This note was uploaded on 05/26/2011 for the course BIO 205 taught by Professor Reed during the Spring '11 term at UNC.

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Lecture10 - 02.08.10 Lecture 10: Cell Communication II GPCR...

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