Lecture11

Lecture11 - 02.11.11 Lecture 11 - The microtubule...

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02.11.11 Lecture 11 - The microtubule cytoskeleton
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The cytoskeleton Gives the cell its shape Allows the cell to organize its components Produces large-scale movements (I.e. muscle contraction, cell crawling, propulsion via cilia and flagella)
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The cytoskeleton is composed of networks of 3 different filaments
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Cytoskeletal filaments exhibit different physical properties
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The cytoskeleton is dynamic
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Microtubules are organized to perform specific functions
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What do microtubules do? Establish an internal polarity to movements and structures in the interphase cell Participate in chromosome segregation during cell division Establish cell polarity during cellular movement Produce extracellular movement via beating of cilia and flagella
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Microtubule structure
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Microtubules exhibit a behavior termed dynamic instability Total mass of polymerized tubulin remains constant, but individual microtubules are dynamic Growth: assembly of microtubule Shrinkage: disassembly of microtubule Catastrophe: switching from growth to shrinking Rescue: switching from shrinking to growth QuickTimeª and a Graphics decompressor are needed to see this pictu
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predominantly at the plus end
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This note was uploaded on 05/26/2011 for the course BIO 205 taught by Professor Reed during the Spring '11 term at UNC.

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Lecture11 - 02.11.11 Lecture 11 - The microtubule...

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