Lecture14

Lecture14 - 02.21.11 Lecture 14 The cell cycle and cell...

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02.21.11 Lecture 14 - The cell cycle and cell death
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The cell cycle: cells duplicate their contents and divide
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The cell cycle may be divided into 4 phases
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The cell cycle triggers essential processes (DNA replication, mitosis)
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Progression of the cell cycle is regulated by feedback from intracellular events
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Cyclin-dependent protein kinases drive progression through the cell cycle Cyclin-dependent kinases (Cdks) are inactive unless bound to cyclins Active complex phosphorylates downstream targets Cyclin helps to direct Cdks to the target proteins
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Cellular levels of (mitotic) M-cyclin rises and falls during the cell cycle M-cyclin levels are low during interphase but gradually increases to a peak level during mitosis M-cdk activity is, likewise, low in interphase but increases in mitosis
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The abundance of cyclins (and the activity of Cdks) is regulated by protein degradation M-cyclin becomes covalently modified by addition of multiple copies of ubiquitin at the end of mitosis
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This note was uploaded on 05/26/2011 for the course BIO 205 taught by Professor Reed during the Spring '11 term at UNC.

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Lecture14 - 02.21.11 Lecture 14 The cell cycle and cell...

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