Lecture15

Lecture15 - 02.23.11 Lecture 15 - Mitosis M for mitosis...

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02.23.11 Lecture 15 - Mitosis
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M for mitosis
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Mitosis is the process that partitions replicated chromosomes equally to 2 daughter cells
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Mitosis proceeds through 6 stages Cytokinesis
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Successful mitosis requires the precise coordination of many processes Packaging of the genome into mitotic chromosomes Regulation of microtubules and motors to build spindle Disassembly of the nuclear membrane Attachment and movement of chromosomes on the spindle Cleavage of a cell into 2 daughters
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Interphase - late G 2 • DNA is duplicated • Cell has doubled in size • Centrosome has duplicated • M-cyclin levels high
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Prophase Chromosomes condense Nuclear envelope breaks down Microtubules reorganize to make asters Centrosomes move to opposite sides of the cell
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Replicated chromosomes are prepared for segregation by cohesins and condensins Cohesins hold sister chromatids together Cohesins are deposited on chromosomes during S-phase
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Replicated chromosomes are prepared for segregation by cohesins and condensins Condensins bind to chromosomes in prophase Molecular motors that “wind” chromatin into small physical packets for mitosis
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The nuclear envelope breaks down and re-forms during mitosis
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Dynamics of the nuclear envelope during cell division
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Lecture15 - 02.23.11 Lecture 15 - Mitosis M for mitosis...

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