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053 apoptosis paper

053 apoptosis paper - Noxa a BH3-Only Member of the Bcl-2...

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DOI: 10.1126/science.288.5468.1053 , 1053 (2000); 288 Science et al. Eri Oda, Candidate Mediator of p53-Induced Apoptosis Noxa, a BH3-Only Member of the Bcl-2 Family and This copy is for your personal, non-commercial use only. . clicking here colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others . here following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles (this information is current as of March 22, 2010 ): The following resources related to this article are available online at www.sciencemag.org http://www.sciencemag.org/cgi/content/full/288/5468/1053 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/288/5468/1053#otherarticles , 18 of which can be accessed for free: cites 41 articles This article 808 article(s) on the ISI Web of Science. cited by This article has been http://www.sciencemag.org/cgi/content/full/288/5468/1053#otherarticles 89 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag.org/cgi/collection/cell_biol Cell Biology : subject collections This article appears in the following registered trademark of AAAS. is a Science 2000 by the American Association for the Advancement of Science; all rights reserved. The title Copyright American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005. (print ISSN 0036-8075; online ISSN 1095-9203) is published weekly, except the last week in December, by the Science on March 22, 2010 www.sciencemag.org Downloaded from
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seals. Although the two harbor seals with prov- en influenza B virus infection displayed respi- ratory symptoms during their rehabilitation pe- riod, this occurred at a time when many of the admitted juvenile seals suffered from lung- worm ( Otostrongylus circumlitus and Parafi- laroides gymnurus ) infections ( 17 ). Associa- tion of lungworm infections in pigs with influ- enza A virus pathogenesis and transmission has been described ( 25 ), but the evidence was con- sidered weak ( 26 ). The combined serological and virological data obtained from seal 99-012 indicate that shedding of influenza B virus in seals was prolonged as compared to shedding in hu- mans ( 27, 28 ) and that IgG antibody respons- es to NP and HA/NA were delayed. Possible explanations for this apparent suboptimal im- mune response upon infection may be asso- ciated with xenobiotic-related immunosup- pression ( 11 ) or the therapeutic use of corti- costeroids to combat the lungworm infections ( 17 ). Prolonged virus shedding in addition to the limited spreading of influenza B virus among seals (as shown in the SRRC and indicated by the limited seroprevalence of specific antibodies in the wild) may explain why little or no genetic and antigenic drift of influenza B virus is observed in seals.
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