APClecture-0311

APClecture-0311 - Colon cancer is the second leading cause...

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Colon cancer is the second leading cause of cancer deaths in the U.S. Polyps, the first stage In tumor development http://www.clevelandclinic.org/registries/inherited/fap.htm
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Colorectal cancer 150,000 cases diagnosed per year (i.e., your chances are 1/18) > 50,000 deaths (2nd to lung cancer) Early detection key >90% 5 year survival with early detection 60% if it has spread locally <10% if it has metastasized Data from ACS
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Colorectal cancer treatment 1. Surgical removal of tumor 1. This can be followed by either Radiation or chemotherapy (fluorouracil) 3. Chemotherapy also used to slow the progress of metastatic disease Data from ACS
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HNPCC 3% of all cases. Defects in mismatch repair. Familial adenomatous polyposis (FAP) 1% of all colon cancers Caused by mutation in a single gene = APC Colon cancer genetics 95% of cases sporadic (no genetic history)
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Familial Adenomatous Polyposis (FAP)
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heriting FAP-related mutations dramatically increase your risk of developing colorectal cancer. 0.2% colorectal cancers by age 50 6% colorectal cancers lifetime risk 93% colorectal cancers by age 50 100% colorectal cancers lifetime risk
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Treatment with an aspirin-like drug called celecoxib (a COX2 inhibitor) led to a 25% reduction in polyp number , and 40% reduction in advanced adenomas. Problem--increased cardiovascular risk. The hope is this will allow doctors to
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This note was uploaded on 05/26/2011 for the course BIO 445 taught by Professor Staff during the Spring '11 term at UNC.

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APClecture-0311 - Colon cancer is the second leading cause...

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