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Muscle Physiology1 - Muscle Physiology Myosin...

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Muscle Physiology Myosin Activation/Deactivation Neuromuscular Junction
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I. Review of Sliding Filament Theory -draw a sarcomere at rest: At rest, myosin is blocked from actin by tropomyosin When Ca ++ binds to troponin , this causes tropomysoin to fall away, exposing actin to myosin Myosin cross bridges reach up, grab onto actin Powerstroke occurs Actin slides over myosin!
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Control of the Sliding Filament Theory Two areas of control: presense of Ca ++ , powerstroke A. Myosin Activation/Deactivation two binding sites on head: 1. actin 2. ATP Activation: Myosin head picks up ATP , immediately splits it into ADP + P + energy, but does not release anything!! Hangs like this until… actin becomes available! Myosin grabs onto actin , releases ADP + P + energy, powerstroke occurs (myosin cross bridges “flip”, now point toward m-line) **only one site can be filled at a time
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B. Myosin Deactivation Powerstroke has just occurred, myosin head is bound to actin and is pointing toward the m-line
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