110304 - Enzyme catalysis-372 Enzyme-substrate properties Gibbs free energy of activated complex Enzyme kinetics CHM3400 Lecture 24 Mar 4 1 Enzyme

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1 CHM3400 - Lecture 24 Mar 4 Enzyme catalysis (Chapter 10 363-372) Enzyme-substrate properties Gibbs free energy of activated complex Enzyme kinetics
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2 Enzyme as catalyst Reaction rate is increased by orders of magnitude (10 6 –10 18 )* in BOTH directions (forward and backwards) Reaction is highly specific for particular substrates, while discriminating against others Catalyst is recycled (not consumed or produced) The catalyst does NOT alter the thermodynamics of the reaction *Cf. age of the Universe = 14 billion year = 31.56x10 6 x 14x10 9 = 4.4x10 17 s age of the Earth = 4.5 billion years = 31.56x10 6 x 4.5x10 9 = 1.4x10 17 s “Lock-key” (outdated) Molecular specificity
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3 Principles of a catalyst A catalyst lowers the Gibbs energy of activation What does this mean in terms of enthalpy and entropy for activated complex? Is Δ r G changed?
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4 Equation Δ Δ = RT H R S h T k k B m m exp exp = RT E A k a exp Is pre-exponential
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This note was uploaded on 05/29/2011 for the course CHM 3400 taught by Professor Seabra during the Spring '08 term at University of Florida.

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110304 - Enzyme catalysis-372 Enzyme-substrate properties Gibbs free energy of activated complex Enzyme kinetics CHM3400 Lecture 24 Mar 4 1 Enzyme

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