MOV470_Diabetes - Diabetes Mellitus Ch 14 Prevelance 15...

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Diabetes Mellitus Ch 14
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Prevelance 15 million (5%) Americans estimated to have DM A precursor of DM is the presence of a impaired fasting glucose (7%) 6 th leading cause of mortality in the US (40,000 deaths a yr) A secondary cause of death
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Description A group of metabolic disorders with a common absolute or relative insufficiency of insulin secretion Inability to secrete or absorb insulin Insulin promotes the transport of glucose across all cell membranes in insulin responsive tissues (skeletal and body fat) Lack of insulin reduces the body’s ability to use glucose as fuel
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Plasma glucose over 160- 180mg/dL causes- Glycosuria: Over spill of plasma glucose in the blood into urine Increases frequency of urine out put Polyuria: Increase in the volume of urine excreted. Increase in water in urine
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Types of DM Type I: Insulin dependent DM Caused by immune system-mediated destruction of the pancreatic beta cells Typically occur under 35 y.o Typically come on very quickly Typically normal body type Type II: Non-insulin dependent Cellular insulin resistance with a relative insulin insufficiency Insulin resistant
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Etiology Genetic predisposition: includes inherited metabolic impairments, accumulation of fat in abdominal region (apple shaped. .3 to 4 times greater) Highly correlated with CVD 80% with DM are obese, waist circumference (men >30 women >40) Reduced HDL Elevated or increased BP
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MOV470_Diabetes - Diabetes Mellitus Ch 14 Prevelance 15...

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