Biochem_Ch. 14 - Chapter 14 Signal-Transduction Pathways...

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Chapter 14 Signal-Transduction Pathways Matching Questions Use the following to answer questions 1-10: Choose the correct answer from the list below. Not all of the answers will be used. a) serpentine receptors b) calmodulin c) fatty acids d) proto-oncogene e) R 2 C 2 f) R 1 C 2 g) cAMP h) phospholipase C i) protein kinase C (PKC) j) epinephrine k) oncogene l) small G proteins 1 ____________ This is a primary messenger that is released by the adrenal gland. Ans: j Section: 14.1 2 ____________ This is another name for the seven-transmembrane helix receptors. Ans: a Section: 14.1 3 ____________ The α and γ subunits of heterotrimeric G proteins are anchored to the cell membrane by being covalently linked to this type of molecule. Ans: c Section: 14.1 4 ____________ This enzyme becomes active when bound to Ca 2+ and diacylglycerol. Ans: i Section: 14.1 5 ____________ This is the inactive form of protein kinase A. Ans: e Section: 14.1 6 ____________ Ras is a member of this family of proteins. Ans: l
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Chapter 14 Signal-Transduction Pathways Section: 14.3 7 ____________ A gene that leads to the transformation of susceptible cell types into cell types with cancerlike characteristics. Ans: k Section: 14.5 8 ____________ This protein binds to calcium ions and serves as a Ca 2+ sensor in eukaryotic cells. Ans: b Section: 14.1 9 ____________ This molecule is considered as a secondary messenger. Ans: g Section: Introduction 10 ____________ This enzyme catalyzes the cleavage of PIP 2 . Ans: h Section: 14.1 Fill in the Blank Questions 11 Protein kinase A phosphorylates serine and ___________ residues. Ans: threonine Section: 14.1 12 ____________ is the membrane protein that catalyzes the conversion of ATP to cAMP. Ans: Adenylate cyclase Section: 14,1 13 The cytosolic side, or β subunit, of the insulin receptor is a ________________ kinase. Ans: tyrosine Section: 14.2 14 The ________ receptor is approximately 50% identical in amino acid sequence with the EGF receptor and has similar domain structure, but it does not bind any known ligand. Ans: Her2 Section: 14.3 15 _______________________ is a secondary messenger and is abbreviated IP 3 . Ans: Inositol 1, 4, 5-trisphosphate Section: Introduction 16 7TM is an abbreviation for _______________________ receptors. Ans: seven-transmembrane-helix Section: 14.1 17 _______________________ binds to β-andrenergic receptors. Ans: Epinephrine, adrenaline Section: 14.1 2
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Chapter 14 Signal-Transduction Pathways 18 The binding of IP 3 to the IP 3 receptor results in the release of __________ from the endoplasmic reticulum. Ans: calcium ion Section: 14.1 19 The catalytically active form of the insulin receptor is a result of phosphorylation of specific ____________ residues in the activation loop. Ans:
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Biochem_Ch. 14 - Chapter 14 Signal-Transduction Pathways...

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