exam 2 book outline - Enzymes accelerate the attainment of...

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Enzymes accelerate the attainment of equilibria but do not shift their positions. The equilibrium position is a function ONLY of the free-energy difference between reactants and products. Chemical reaction of substrate S to form product P does through a transition state that has a higher free energy than either S or P. Double dagger denotes the transition state o The transition state is the one least stable and the most seldom occupied because it has the highest free energy o The difference between the free energy of the transition state and the substrate is the Gibbs free energy of activation or simply activation energy Enzymes facilitate the formation of the transition state; lower the activation energy o The rate of reaction is proportional to the concentration of transition state o The concentration of transition state at equilibrium is related to the Gibbs free energy of activation (free energy difference between the transition state and the substrate) The greater the difference, the smaller the concentration of transition state
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This note was uploaded on 05/30/2011 for the course BIOCHEMIST 4033 taught by Professor Dorristerry during the Fall '10 term at Florida A&M.

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exam 2 book outline - Enzymes accelerate the attainment of...

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