Drugs Affecting Corticosteroid Levels

Drugs Affecting Corticosteroid Levels - Drugs Affecting...

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Drugs Affecting Corticosteroid Levels
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Glucocorticosteroids Used for replacement therapy in patients with inadequate adrenal function Glucocorticoids – produced by adrenal gland Cortisol (hydrocortisone) and cortisone No anti-inflammatory systemic activity Oral, topical, ophthalmic, inhalers, nasal, parenteral
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Glucocorticoids Therapeutic uses Anti-inflammatory Immunosuppression Adrenal insufficiency Adjunct – malignant disorders Adverse Effect High dose - suppress HPA axis Abruptly stop – acute adrenal insufficiency Taper dose
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Prednisone Pharmacotherapeutics Anti-inflammatory Immunosuppression Replacement Short-term therapy Long-term
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Prednisone Pharmacokinetics Readily absorbed from GI tract Metabolized in liver to active form –prednisolone Excreted in urine Crosses placenta, enters breast milk
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Prednisone Pharmacodynamics Glucocorticoid activity mainly Increased mineralcorticoid activity with higher doses
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This note was uploaded on 05/30/2011 for the course NUR 212 taught by Professor Susanhampson during the Spring '11 term at St. Xavier.

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Drugs Affecting Corticosteroid Levels - Drugs Affecting...

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