Drugs Affecting Thyroid Function

Drugs Affecting Thyroid Function - Drugs Affecting Thyroid...

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Drugs Affecting Thyroid Function
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Thyroid Gland Function Thyroid hormones Influence every organ system Control cellular metabolism Promote normal growth and development Metabolism of fats, carbohydrates and protein Regulate heat and energy production Regulate blood volume, cardiac output oxygen consumption
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Thyroid Gland Function Regulated by hypothalamic-pituitary-thyroid feedback system Hypothalamus produces TRH Controls release of TSH from anterior pituitary gland TSH increases release of thyroid hormones Thyroid hormones Thyroxine T4 Triiodothyronine T3
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Thyroid Gland Dysfunction Hyperthyroidism – excess amount S/S overactive cellular metabolism Graves Disease – autoimmune disorder Hypothyroidism Congenital - Cretinism Acquired Lifelong replacement
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Levothyroxine (T4) Synthroid Pharmacotherapeutics Replacement therapy in hypothyroidism Suppress release of TSH from pituitary gland Treat hypothyroidism d/t cancer Treat myxedema coma
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Levothyroxine (T4) Pharmacokinetics Absorption varies; increased during fasting states T4 converted to T3 for clinical effect Slow onset of effects with oral route Metabolized in liver, excreted in bile Crosses placenta, enters breast milk Pharmacodynamics Replaces natural thyroid hormone
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Levothyroxine (T4) Contraindications Hypersensitivity Thyrotoxicosis Acute MI Precautions Pregnancy Cat. A Lactation CAD DM, Adrenal insufficiency
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This note was uploaded on 05/30/2011 for the course NUR 212 taught by Professor Susanhampson during the Spring '11 term at St. Xavier.

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Drugs Affecting Thyroid Function - Drugs Affecting Thyroid...

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