08.PMCB.lecture10 - Plant Molecular and Cellular Biology...

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9/10/2008 1 Plant Molecular and Cellular Biology Lecture 10: Plant Cell Cycle Gary Peter
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9/10/2008 PMCB Lecture 9: G. Peter 2 Learning Objectives z Explain similarities and differences between fungal, mammalian and plant cell cycles z Explain the role of the cell cycle machinery in plant development
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Plant Cell Cycle is Conserved 9/10/2008 PMCB Lecture 9: G. Peter 3 De Veylder et al., 2007 Nature Rev. MCB 8: 655-665
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9/10/2008 PMCB Lecture 9: G. Peter 4 Plant CDK, Cyclin Regulators are Conserved: All Predicted Arabidopsis CDKs and Cyclins The Plant Cell, Vol. 14, 903–916, April 2002 Arabidopsis thaliana has 12 distinct bona fide CDKs and more than 49 different cyclins
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CDKs 9/10/2008 PMCB Lecture 9: G. Peter 5 z CDK classifications based on conserved sequences corresponds well with their functional diversity. z The major drivers of the plant cell cycle are the A- and B- type CDKs. z A-type CDKs (CDKA) are most similar to mammalian CDK1 and CDK2 , they are constitutively present during the cell cycle, and they control the G1–S and G2–M transitions. z B-type CDKs (CDKB) are specific to plants and their accumulation depends on the phase of the cell cycle, they reach a maximum level at the G2–M transition, the phase at which their activity is required.
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Cyclins 9/10/2008 PMCB Lecture 9: G. Peter 6 z Cell-cycle progression requires the sequential association of the CDKs with different types of cyclin. z D-type cyclins (CYCD) regulate the G1–S transition, although there is accumulating evidence that they also might have a role in the G2–M transition.
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08.PMCB.lecture10 - Plant Molecular and Cellular Biology...

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