Chapter 7 DNA stucture

Chapter 7 DNA stucture - DNA Structure Chapter 7 (p265-275)...

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Unformatted text preview: DNA Structure Chapter 7 (p265-275) Suggested problems: #1, 11, 24 Outline: A. Experiments showing that DNA is the genetic material 1. DNA can transform nonvirulent bacteria into virulent (Griffith, Avery/MacLeod/McCarty) 2. The genetic material of phages is DNA (Hershey-Chase) A. DNA structure 1. Historical discoveries (Chargaff, Watson and Crick, Franklin and Wilkins) 2. Base composition and organization 1. Griffith observed that virulent Streptococcus bacteria, when heat-inactivated and mixed with a nonvirulent strain, could “transform” the nonvirulent strain and make it virulent (1928). Two experiments showed that DNA is the genetic material Which component of the dead donor cells caused transformation? Avery, McLeod, and McCarty (1944):-individually destroyed components,-found that DNA is the transforming agent 2. Hershey-Chase experiment (1952): -radiolabeled either the DNA or the protein in a bacteriophage-found that only labeled DNA ended up inside the cell Two experiments showed that DNA is the genetic material What is DNA made of? DNA had to have three properties: 1. The structure must allow a mechanism for faithful replication. 1. DNA must have informational content....
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This note was uploaded on 05/28/2011 for the course BIO 220 taught by Professor Dr.leatherman during the Spring '10 term at N. Colorado.

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Chapter 7 DNA stucture - DNA Structure Chapter 7 (p265-275)...

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