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Chapter 7 DNA stucture

Chapter 7 DNA stucture - DNA Structure Chapter 7(p265-275...

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DNA Structure Chapter 7 (p265-275) Suggested problems: #1, 11, 24
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Outline: A. Experiments showing that DNA is the genetic material 1. DNA can transform nonvirulent bacteria into virulent (Griffith, Avery/MacLeod/McCarty) 2. The genetic material of phages is DNA (Hershey-Chase) A. DNA structure 1. Historical discoveries (Chargaff, Watson and Crick, Franklin and Wilkins) 2. Base composition and organization
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1. Griffith observed that virulent Streptococcus bacteria, when heat-inactivated and mixed with a nonvirulent strain, could “transform” the nonvirulent strain and make it virulent (1928). Two experiments showed that DNA is the genetic material
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Which component of the dead donor cells caused transformation? Avery, McLeod, and McCarty (1944): -individually destroyed components, -found that DNA is the transforming agent
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2. Hershey-Chase experiment (1952): -radiolabeled either the DNA or the protein in a bacteriophage -found that only labeled DNA ended up inside the cell Two experiments showed that DNA is the genetic material
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What is DNA made of?
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DNA had to have three properties: 1. The structure must allow a mechanism for faithful replication. 1. DNA must have informational content. 1. DNA must have the ability to change, to account for mutations.
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Chargaff’s rules: 1.
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