2011-04-19 -- Genomic Medicine

2011-04-19 -- Genomic Medicine - Genomic and Post-Genomic...

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Unformatted text preview: Genomic and Post-Genomic Medicine April 19, 2011 History 451 Prof. November Why DNA Matters Watson and Cricks 1953 elucidation of the structure of DNA provided an explanation for how life replicates and regulates All cells, all organisms* unified by presence of nucleic acids DNA could let us read genes DNA is consistent with known physical and chemical laws (Sorry, Erwin and Max!) Convergence of physics, chemistry, biology Linus Paulings Toys Linus Pauling (1901-1994) Ball and Stick models of complex molecules Proteins Amino acids Nucleic acids Alpha-Helix Watson and Crick James Watson (1928) University of Chicago B.Sc. 1947 Salvador Lurias protg, Indiana University Satellite lab of Caltech Phage Group Ph.D. 1950 (Indiana U.) Francis Crick (1916-2004) UCL, B.Sc. 1937 WWII research on mines meets many others interested in physics Pursues Ph.D. in molecular biology starting in 1947 We have discovered the secret of life Erwin Chargaff drops by Cambridge (1952) Tells Crick about curious observation he made about proportions of nucleotides in DNA samples: no matter where the DNA came from proportions of adenine and thymine are the same AND proportions of guanine and cytosine are the same Other researchers...
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2011-04-19 -- Genomic Medicine - Genomic and Post-Genomic...

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