2011-04-19 -- Genomic Medicine

2011-04-19 -- Genomic Medicine - Genomic and Post-Genomic...

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Unformatted text preview: Genomic and Post-Genomic Medicine April 19, 2011 History 451 Prof. November Why DNA Matters • Watson and Crick’s 1953 elucidation of the structure of DNA provided an explanation for how life replicates and regulates • All cells, all organisms* unified by presence of nucleic acids • DNA could let us read genes • DNA is consistent with known physical and chemical laws (Sorry, Erwin and Max!) – Convergence of physics, chemistry, biology Linus Pauling’s Toys • Linus Pauling (1901-1994) • “Ball and Stick” models of complex molecules – Proteins – Amino acids – Nucleic acids • Alpha-Helix Watson and Crick • James Watson (1928) – University of Chicago B.Sc. 1947 – Salvador Luria’s protégé, Indiana University • Satellite lab of Caltech Phage Group – Ph.D. 1950 (Indiana U.) • Francis Crick (1916-2004) – UCL, B.Sc. 1937 – WWII research on mines – meets many others interested in physics – Pursues Ph.D. in “molecular biology” starting in 1947 “We have discovered the secret of life” • Erwin Chargaff drops by Cambridge (1952) – Tells Crick about curious observation he made about proportions of nucleotides in DNA samples: • no matter where the DNA came from proportions of adenine and thymine are the same AND proportions of guanine and cytosine are the same – Other researchers...
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This note was uploaded on 06/02/2011 for the course HIST 451 taught by Professor November during the Spring '11 term at South Carolina.

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2011-04-19 -- Genomic Medicine - Genomic and Post-Genomic...

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