2011-04-19 -- Genomic Medicine

2011-04-19 -- Genomic Medicine - Genomic and Post-Genomic...

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Genomic and Post-Genomic Medicine April 19, 2011 History 451 Prof. November
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Why DNA Matters Watson and Crick’s 1953 elucidation of the structure of DNA provided an explanation for how life replicates and regulates All cells, all organisms* unified by presence of nucleic acids DNA could let us read genes DNA is consistent with known physical and chemical laws (Sorry, Erwin and Max!) Convergence of physics, chemistry, biology
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Linus Pauling’s Toys Linus Pauling (1901-1994) “Ball and Stick” models of complex molecules Proteins Amino acids Nucleic acids Alpha-Helix
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Watson and Crick James Watson (1928) University of Chicago B.Sc. 1947 Salvador Luria’s protégé, Indiana University Satellite lab of Caltech Phage Group Ph.D. 1950 (Indiana U.) Francis Crick (1916-2004) UCL, B.Sc. 1937 WWII research on mines – meets many others interested in physics Pursues Ph.D. in “molecular biology” starting in 1947
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“We have discovered the secret of life” Erwin Chargaff drops by Cambridge (1952) Tells Crick about curious observation he made about proportions of nucleotides in DNA samples: no matter where the DNA came from proportions of adenine and thymine are the same AND proportions of guanine and cytosine are the same Other researchers
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