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2005_campbl07 - Chapter 7 Membrane Structure and Function...

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Chapter 7: Membrane Structure and Function
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Important Point:
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Lipid Bilayer The “ability of the cell to discriminate in its chemical exchanges with the environment is fundamental to life, and it is the plasma membrane that makes this selectivity possible.”
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Fluid Mosaic Model
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History of Fluid Mosaic Model For more on this history, see: http://www1.umn.edu/ships/9-2/membrane.htm
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Movement of Phospholipids
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Membrane Fluidity
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Cholesterol: Temp. Buffer “Cholesterol reduces membrane fluidity at moderate temperatures by reducing phospholipid movement, but at low temperatures it hinders solidification by disrupting regular packing of phospholipids.” Campbell & Reece (2005) p. 126
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Lateral Movement of Proteins Protein diffusion is not as fast as phospholipid diffusion
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Not all Proteins Move Proteins attached to cytoskeleton or ECM don’t move
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Transmembrane Protein Know definition of transmembrane protein Note distinct orientation
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Membrane Proteins
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Membrane Protein Functions Membrane asymmetry allows cells to automatically differ their intracellular environment from that existing extracellularly
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Membrane Protein Functions
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Membrane Protein Trafficking Note the orientation of
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