2005_campbl16 - Important Point Chromosomes consist of both...

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1 Chapter 16: The Molecular Basis of Inheritance Important Point: The Hereditary Material Chromosomes consist of both DNA and Protein DNA was discovered before its role in heredity was understood People had a sense that chromosomes embodied inheritance before they understood that DNA was the hereditary material People did not want to believe that DNA was the hereditary material since it is not complex enough Instead, people believed that proteins must be the hereditary material—they were wrong Transformation (I.e., Griffith’s experiment, which is mediated by DNA) was discovered before it was understood that it was mediated by DNA Transformation Griffith, 1928 Transforming Principle Sensitivity to DNase Hi, I’m Oswald Avery. I figured out that the transforming principle is DNA! Avery, MacLeod, McCarty (1944) I did this by treating transforming principle with different enzymes, proteases, RNases, DNases… only DNase destroyed its activity Avery, MacLeod, McCarty (1944) Colin M. MacLeod, Maclyn McCarty, Detlev Wulf Bronk,
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