campbl11 - Chemical Signaling Between Cells Three general...

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Chemical Signaling Between Cells Three general categories of chemical signaling: Cytoplasmic connections between cells Cell-to-cell contact-mediated signaling Free diffusion between cells Distant cells (hormones) Adjacent cells (within interstitial space) All of latter involves the physical movement of Ligands That is, Ligand Reception by a Protein Note that Reception means Molecule-to-Molecule Contact
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Chemical Signaling Between Cells
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Long-Distance Diffusion Note how specificity is determined by receptor protein Note dependence on Systemic Circulation (blood/lymph)
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Local Diffusion e.g., Histamine released from damaged cells in inflammation e.g., Interferon release by viral-infected cells
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Local Diffusion Note both absence of and lack-of-dependence on Systemic Circulation
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Signal-Transduction Emphasis This chapter’s emphasis is on signals that are released from one cell and allowed to freely diffuse to a second (or more) recipient cell(s) These communications are deliberately initiated, received, and interpreted in order to increase the physiological coordination of the cells in multicellular organisms We will consider in particular those events that follow the reception of chemical signals We will not dwell on the purpose of the signal We also will not dwell on why and how a given cell released a given signal
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campbl11 - Chemical Signaling Between Cells Three general...

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